全文获取类型
收费全文 | 8251篇 |
免费 | 1310篇 |
国内免费 | 1817篇 |
专业分类
化学 | 6214篇 |
晶体学 | 205篇 |
力学 | 400篇 |
综合类 | 169篇 |
数学 | 1367篇 |
物理学 | 3023篇 |
出版年
2024年 | 11篇 |
2023年 | 141篇 |
2022年 | 239篇 |
2021年 | 294篇 |
2020年 | 340篇 |
2019年 | 353篇 |
2018年 | 306篇 |
2017年 | 365篇 |
2016年 | 341篇 |
2015年 | 452篇 |
2014年 | 511篇 |
2013年 | 722篇 |
2012年 | 711篇 |
2011年 | 744篇 |
2010年 | 612篇 |
2009年 | 628篇 |
2008年 | 737篇 |
2007年 | 643篇 |
2006年 | 585篇 |
2005年 | 439篇 |
2004年 | 324篇 |
2003年 | 234篇 |
2002年 | 262篇 |
2001年 | 200篇 |
2000年 | 227篇 |
1999年 | 145篇 |
1998年 | 102篇 |
1997年 | 76篇 |
1996年 | 53篇 |
1995年 | 47篇 |
1994年 | 56篇 |
1993年 | 51篇 |
1992年 | 37篇 |
1991年 | 25篇 |
1990年 | 31篇 |
1989年 | 35篇 |
1988年 | 31篇 |
1987年 | 26篇 |
1986年 | 16篇 |
1985年 | 26篇 |
1984年 | 19篇 |
1983年 | 14篇 |
1982年 | 15篇 |
1981年 | 11篇 |
1980年 | 19篇 |
1979年 | 14篇 |
1978年 | 22篇 |
1977年 | 16篇 |
1976年 | 12篇 |
1975年 | 12篇 |
排序方式: 共有10000条查询结果,搜索用时 500 毫秒
1.
Dan Chen Kaixin Du Xiaochen Niu Hongwei Zhang Xue Zhang Yu Tang Jianchun Zhao 《Biomedical chromatography : BMC》2022,36(3):e5288
Amlexanox, an anti-inflammatory and anti-allergic agent, has been widely used clinically for the treatment of canker sores, asthma, and allergic rhinitis. Recently, amlexanox has received considerable attention in curing nonalcoholic fatty liver diseases and hepatitis virus infection. Herein, we first established a sensitive high-performance liquid chromatography-tandem mass spectrum (LC–MS/MS) method for the determination of amlexanox in rat plasma. Propranolol was used as the internal standard (IS). Using a simple protein precipitation method, the amlexanox and IS were separated with Capcell Pak C18 column (2.0 × 50 mm, 5 μm) and eluted with water and acetonitrile each containing 0.1% formic acid using gradient elution condition at a flow rate of 0.4 mL·min−1. Amlexanox and IS were detected by a triple quadrupole mass in multiple reactive monitoring (MRM) under the transitions of m/z 299.2 → 281.2 and m/z 259.9 → 116.1 with positive electrospray ionization, respectively. The calibration curves of amlexanox were established with the range of 50 to 2000 ng·mL−1 (r2 > 0.99). The validation method consisted of selectivity, accuracy, precision, carryover effect, matrix effect, recovery, dilution effect, and stability. The fully validated method was successfully applied to the pharmacokinetic study of amlexanox in Wistar rats. 相似文献
2.
Yujie Gao Zhiye Qiu Lei Liu Mengmeng Li Bingjie Xu Dan Yu Dongming Qi Jindan Wu 《Journal of polymer science. Part A, Polymer chemistry》2022,60(15):2191-2212
Refractory wounds have always been an important issue to healthcare systems, whose healing process is always delayed by multiple factors, including bacterial infections, chronic inflammation, and excessive exudates, etc. Employing multifunctional wound dressings is recognized as an effective strategy to deal with refractory wounds, which has yielded promising outcomes in recent years. Among these advanced wound dressings, fibrous dressings have gained growing attention due to their unique merits. Such wound dressings have demonstrated great potential in delivering theranostic agents, such as antibacterial agents, anti-inflammatory drugs, growth factors, and diagnostic probes, etc., for the purposes of accelerating wound healing. This paper reviews the development of multifunctional fibrous dressings and their applications in treating refractory wounds. The construction approaches of novel fibrous dressing with capabilities of antibacterial, anti-inflammation, exudate management and diagnosis were also introduced. Furthermore, the existing problems and challenges are also discussed briefly. 相似文献
3.
Analysis and pharmacokinetic study of polyphyllin H in beagle dog plasma after oral administration of Rhizoma Paridis Extracts by LC‐MS/MS 下载免费PDF全文
4.
采用粉末冶金法向铜基金属结合剂中引入玻璃料,结合材料电子万能试验机、洛氏硬度仪、SEM等检测方法,研究了玻璃料加入对铜基金属结合剂及金刚石磨具的影响.结果表明,随着玻璃料含量的增加,铜基结合剂的抗折强度和抗冲击强度呈下降的趋势,其硬度呈逐渐上升趋势,硬脆相的引入提高了铜基金属结合剂的自锐性;玻璃相和金属相之间结合紧密,两相之间化学元素在界面处发生相互扩散;玻璃料的加入使结合剂对磨料的包裹更加紧密,大大提高了结合剂对金刚石的把持力,有利于增加金刚石磨具寿命及加工效率. 相似文献
5.
6.
Science China Chemistry - 相似文献
7.
Xiaoshuang Luo Xinxian Qin Zhengyi Liu Dan Chen Weiwei Yu Kankan Zhang Deyu Hu 《Biomedical chromatography : BMC》2020,34(1):e4694
A simple and rapid analytical method for the detection of trifloxystrobin, trifloxystrobin acid and tebuconazole in soil, brown rice, paddy plants and rice hulls was established and validated by liquid chromatography with tandem mass spectrometry. Acceptable linearity (R2 > 0.99), accuracy (average recoveries of 74.3–108.5%) and precision (intra- and inter-day relative standard deviations of 0.9–8.8%) were obtained using the developed determination approach. In the field trial, the half-lives of trifloxystrobin and tebuconazole in paddy plants were 5.7–8.3 days in three locations throughout China, and the terminal residue concentrations of trifloxystrobin and tebuconazole were <100 and 500 μg/kg (maximum residue limits set by China), respectively, at harvest, which indicated that, based on the recommended application procedure, trifloxystrobin and tebuconazole are safe for use on rice. The risk assessment results demonstrated that, owing to risk quotient values of both fungicides being <100%, the potential risk of trifloxystrobin and tebuconazole on rice was acceptable for Chinese consumers. These data could provide supporting information for the proper use and safety evaluation of trifloxystrobin and tebuconazole in rice. 相似文献
8.
Sha Xia Dan Wang Nian-Ke Chen Dong Han Xian-Bin Li Hong-Bo Sun 《Annalen der Physik》2020,532(3):1900318
Defects play a central role in controlling the electronic properties of two-dimensional (2D) materials and realizing the industrialization of 2D electronics. However, the evaluation of charged defects in 2D materials within first-principles calculation is very challenging and has triggered a recent development of the WLZ (Wang, Li, Zhang) extrapolation method. This method lays the foundation of the theoretical evaluation of energies of charged defects in 2D materials within the first-principles framework. Herein, the vital role of defects for advancing 2D electronics is discussed, followed by an introduction of the fundamentals of the WLZ extrapolation method. The ionization energies (IEs) obtained by this method for defects in various 2D semiconductors are then reviewed and summarized. Finally, the unique defect physics in 2D dimensions including the dielectric environment effects, defect ionization process, and carrier transport mechanism captured with the WLZ extrapolation method are presented. As an efficient and reasonable evaluation of charged defects in 2D materials for nanoelectronics and other emerging applications, this work can be of benefit to the community. 相似文献
9.
10.